Friday, January 25, 2013

Mitsubishi recalls 14,700 electric cars globally over brakes

TOKYO (Reuters) - Mitsubishi Motors Corp said it would recall about 14,700 electric vehicles (EV) globally due to a brake problem unique to the electric-motor powered cars in one of the biggest callbacks involving the new generation of eco-friendly cars.

Mitsubishi Motors said that in Japan it would recall nearly 3,400 i-MiEV electric vehicles, as well as more than 2,400 MINICAB-MiEV vehicles.

Overseas, mostly in Europe, it said it was recalling about 8,900 i-MiEV vehicles. Some of those are sold as PSA Peugeot Citroen's iOn and C-Zero, though Mitsubishi declined to say how many.

The EV recall by Mitsubishi is small compared to recalls of conventional petrol-driven vehicles which have numbered in the millions, though it accounts for nearly half of their overall i-MiEV and MINICAB-MiEV production.

Electric vehicles are struggling to make inroads into the autos sector despite a big push by the Obama administration to boost sales, as the green cars often fall short of consumer expectations especially in running distance.

"This is a matter of one part, and it's too much to apply the issue to say there is something wrong with electric vehicles," said Tatsuo Yoshida, a senior analyst at Mitsubishi UFJ Morgan Stanley Securities in Tokyo.

"The cause of the problem is identified and there were no accidents. But the problematic part is the brake, an important part for safety, and that means Mitsubishi Motors' quality check procedure is too weak."

The recalled vehicles may carry an improperly shaped or damaged electric pump, which sends air to the brake booster, the Japanese automaker said. The brake booster multiplies the forces applied from the foot and makes braking easier.

A problematic pump may cause the vehicle to run a longer distance when braking before it comes to a complete halt, a spokesman said. No injuries or deaths have been reported and there is no risk of fire, he added.

He declined to comment on the cost of the recall. The problematic part will be exchanged and the process will take about half an hour, the spokesman, who declined to be named, said.

The pump is not used in conventional cars, as the engine sends air to the brake booster.

The recall is one of the biggest involving electric vehicles. In August 2012, Fisker Automotive recalled 2,400 Karma plug-in hybrids to repair a faulty cooling fan unit that was the cause of a vehicle fire.

In Jan 2012, General Motors offered to fix the battery pack for the 8,000 Volt plug-in hybrids to eliminate the risk of a fire being triggered days after a crash.

Sales of electric cars make up only a small percentage of the overall autos market. In 2012, Nissan sold 9,819 of its world's best-selling EV, the Leaf, in the United States, where 14.5 million vehicles were sold in total.

Mitsubishi Motors has sold or exported a total of around 27,200 i-MiEVs since it first went on sale in July 2009.

The recall comes a month after Mitsubishi Motor was inspected by Japan's Transport Ministry, which said the automaker inappropriately reported about recalls involving minicars.

Mitsubishi Motors has been mired in a string of recall scandals including in 2000, when an insider's tip revealed the automaker had been hiding customer complaints illegally for over two decades.

(Reporting by Yoko Kubota; Editing by Richard Pullin and Jeremy Laurence)

Source: http://news.yahoo.com/mitsubishi-recalls-14-700-electric-cars-globally-over-074022127--sector.html

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Interviews: Ask What You Will of Paleontologist Jack Horner

John "Jack" R. Horner is the Curator of Paleontology at the Museum of the Rockies, adjunct curator at the National Museum of Natural History, and one of the most famous paleontologists in the world. Known in the scientific community for his research on dinosaur growth and whether or not some species lived in social groups, he is most famous for his work on Jurassic Park and being the inspiration for the character of Alan Grant. Horner caused quite a stir with the publication of his book, How to Build a Dinosaur: Extinction Doesn't Have to Be Forever, in which he proposes creating a "chickensaurus" by genetically "nudging" the DNA of a chicken. Jack has agreed to step away from the genetics lab and put down the bones in order to answer your questions. As usual, you're invited to ask as many questions as you'd like, but please divide them, one question per post.

Source: http://rss.slashdot.org/~r/Slashdot/slashdotScience/~3/zMlhGDZSSNo/story01.htm

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Thursday, January 24, 2013

Clark Howard: It's not so easy to cut cable or satellite TV | Atlanta ...

Consumer expert Clark Howard?s column appears here each Thursday in conjunction with Deal Spotter, a weekly print section in The Atlanta Journal-Constitution.

Listen to Clark's live radio show 8-10 p.m. weekdays on AM750 and 95.5FM News/Talk WSB.

Listen to Clark's live radio show 8-10 p.m. weekdays on AM750 and 95.5FM News/Talk WSB.

Have you cut the cord from pay TV yet? The latest numbers from Nielsen indicate that 5.1 million households are getting over-the-air reception and supplementing it with Internet-delivered pay programming. That trend is up by roughly 25 percent, according to The Wall Street Journal. Meanwhile, the average American household pays about $800 annually for cable and around $1,000 for satellite. It?s a battle I?m waging at our house. We?re with an expensive satellite player and I?ve floated the trial balloon with my wife and kids about cutting the cord entirely ? they?re not having it. For me, it would be no big sacrifice because the only thing I watch on TV is the NFL. I would lose a handful of Monday night and Thursday night games, but the rest of the games are on regular network TV. It?s similar to when cellphones became ubiquitous some 10 years ago. There was a lot of talk about people cutting the landline, but it was more like a drop here and a drop there of people doing it. However, now that it?s 10 years later, you have monopoly local phone companies reporting big losses in customer numbers every quarter. I think it will be a similar slow progression with pay TV. For many, the process starts with cutting back on your package. It?s also a great idea to shop your plan. Many people now have access to four providers ?? two satellite companies, one cable company and a monopoly phone company providing TV. Pit them against each other and let them slug it out so you can get the best deal. And remember, loyalty hurts. A new customer at any pay TV provider can get an introductory deal with a contract. Find more answers to your consumer questions at Clark?s website. And get more savings tips from Clark?s previous blog posts. ? Clark Howard ? Save More, Spend Less, Avoid Rip-offs ? for the Atlanta Bargain Hunter blog

Source: http://blogs.ajc.com/atlanta-bargain-hunter/2013/01/24/clark-howard-its-not-so-easy-to-cut-cable-or-satellite-tv/?cxntfid=blogs_atlanta_bargain_hunter

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Bowers & Wilkins A7: This Thing Is So Good. This Thing Is So Expensive.

Bowers & Wilkins makes some of our favorite audio hardware. We also happen to love AirPlay—so the union of the two should be terrific, right? Sort of. The A7 speaker is tremendous—but it's just so, so expensive. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/KxuBXRcbCAA/bowers--wilkins-a7-this-thing-is-so-good-but-nobody-can-afford-it

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Sunday, January 20, 2013

Russia plans biggest war games since Soviet era

Some see the naval exercises scheduled later this month as cover for a massive evacuation of Russian citizens from war-torn Syria.

By Fred Weir,?Correspondent / January 3, 2013

People walk along the Admiralteyskaya Embankment in front of a Russian naval ship in the center of St. Petersburg in July. Russia is planning a massive naval exercise ? its largest war games since the Soviet era ? for later this month.

Alexander Demianchuk/Reuters

Enlarge

The Russian Navy has announced that it will hold its biggest war games since Soviet times in the Mediterranean and Black seas later this month.

Skip to next paragraph Fred Weir

Correspondent

Fred Weir has been the Monitor's Moscow correspondent, covering Russia and the former Soviet Union, since 1998.?

Recent posts

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The ambitious exercises, which will involve ships from all four major Russian fleets, are a sign of growing confidence on the part of Russia's military as it begins to enjoy the benefits of President Vladimir Putin's huge budget allocations for renewing and reequipping all branches of the armed forces.

The purpose of the war games will be to strengthen integration between different types of forces and gain practice with major military deployments outside Russia's immediate neighborhood, the Defense Ministry said in a statement Tuesday.

As part of the maneuvers, naval ships will arrive at an "unprepared" coast in the Russian northern Caucasus region to take amphibious troops onto transport vessels.

"The primary goal of the exercise is to train issues regarding formation of a battle group consisting of troops of different branches outside of the Russian Federation, planning its deployment and managing a coordinated action of a joint Navy group in accordance with a common plan," the ministry's statement said.

The participating ships, it said, will be drawn from all of Russia's four major naval formations: the Northern, Baltic, Pacific, and Black Sea fleets.

Some experts suggest the war games may be cover for an increasingly nervous Moscow's preparations to evacuate Russian citizens and their dependents from war-torn Syria.

About 9,000 Russians are registered with the Russian Embassy in Damascus, but some experts say the full number may be 30,000 or more. Over the nearly half a century that Moscow has enjoyed good relations with Syria, thousands of Russian women have married Syrian men and moved to the country. Many of them may urgently demand to return with their children to Russia if the situation turns critical.

This week the Russian Navy refreshed a fleet, including several huge amphibious assault ships capable of carrying thousands of people, which it had deployed to the eastern Mediterranean last summer.

Experts say the replacement fleet dispatched this week is of similar makeup, with at least five huge troop-transport ships at its core.

As part of Russia's eight-year, $659 billion rearmament program, the Navy is slated to receive 50 new warships by 2016, including new Borey-class nuclear-powered ballistic-missile submarines ? a third of which entered service last weekend ? 18 major surface warships, and dozens of special purpose and support vessels.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/6YylKnknf94/Russia-plans-biggest-war-games-since-Soviet-era

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No Comments - Yeshiva World News

Based on the calculations involving the number of eligible voters, the number of votes that are disqualified on the average and other factors, it appears the ?minimum threshold? for entering the 19th Knesset will be about 70,000 votes.

That means if any of the smaller parties vying for seats in Knesset do not earn 70,000 votes, they will not be in the Knesset and those votes will be lost. At one point, a small party could enter Knesset with far less votes, only required to earn one seat, but that was changed in the hope of eliminating some of the smaller parties which were viewed as counterproductive.

The calculations regarding the number of votes that back each seat in Knesset is estimated to be about 30,000.

There are 120 Knesset seats. While it is generally the case, a cabinet member does not necessarily have to be a MK, as is the case with Minister of Justice Prof. Yuval Ne?eman.

(YWN ? Israel Desk, Jerusalem)

Source: http://www.theyeshivaworld.com/?p=153296

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Video: Making healthy food accessible to seniors

Source: http://www.msnbc.msn.com/id/40153870/vp/50514251#50514251

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Sharapova rocks after win over Venus in Australia

Russia's Maria Sharapova celebrates after defeating Venus Williams of the US in their third round match at the Australian Open tennis championship in Melbourne, Australia, Friday, Jan. 18, 2013. (AP Photo/Dita Alangkara)

Russia's Maria Sharapova celebrates after defeating Venus Williams of the US in their third round match at the Australian Open tennis championship in Melbourne, Australia, Friday, Jan. 18, 2013. (AP Photo/Dita Alangkara)

Russia's Maria Sharapova celebrates after defeating Venus Williams of the US in their third round match at the Australian Open tennis championship in Melbourne, Australia, Friday, Jan. 18, 2013. (AP Photo/Dita Alangkara)

Russia's Maria Sharapova celebrates after defeating Venus Williams of the US in their third round match at the Australian Open tennis championship in Melbourne, Australia, Friday, Jan. 18, 2013. (AP Photo/Dita Alangkara)

Venus Williams of the US reacts during her third round loss to Russia's Maria Sharapova at the Australian Open tennis championship in Melbourne, Australia, Friday, Jan. 18, 2013. (AP Photo/Dita Alangkara)

El serbio Novak Djokovic logra esforzadamente una devoluci?n al checo Radek Stepanek en el partido que eventualmente gan? el viernes 18 de enero de 2013 para ubicarse enla cuarta ronda del Abierto de Australia en Melbourne. (Foto AP/Dita Alangkara)

(AP) ? Maria Sharapova leaned back and pumped her arms. She ripped her elbows back and forth, screaming after her victory. Four pumps, five ? she rocked forward ? six pumps. More.

Sharapova had just defeated Venus Williams 6-1, 6-3 Friday, her first victory over the seven-time major winner in a Grand Slam. This was a match clearly worth celebrating, but it was if Sharapova had won the Australian Open title eight days early.

"I was just really pumped," she said. "Why shouldn't I be?"

After back-to-back 6-0, 6-0 wins in the first two rounds ? the first time that happened at major since 1985 ? Sharapova has conceded the fewest number of games en route to the fourth round at the Australian Open since Steffi Graf did so 24 years ago. Graf also lost only four games in her first three matches on her way to the second of her three consecutive titles in Melbourne.

Sharapova knows she must stay on top of her game. Another Williams could be waiting. Since Sharapova won the French Open, to complete a career Grand Slam of all four major titles, Serena Williams has won just about everything.

Asked if she was thinking about a showdown with the younger of the Williams sisters, Sharapova said: "She's on the other side of the draw, and other players are on the other side of the draw as well."

That means they can meet only in the final.

"Until you get to that stage, and if you do, if you're facing each other," she said, "that's the point when you're thinking about that particular opponent."

The top two contenders on the opposite side of the draw, defending champion Victoria Azarenka and Serena Williams, play one after the other at Rod Laver Arena on Saturday. Top-ranked Azarenka is first up against American Jamie Hampton, followed by Williams against Ayumi Morita of Japan.

U.S. Open champion Andy Murray follows them in a third-round match against occasional hitting partner Ricardas Berankis, a qualifier from Lithuania. Four-time Australian Open champion Roger Federer has the night match against Bernard Tomic, the last Aussie in the men's or women's draws.

Top-ranked Novak Djokovic took another step closer to a third consecutive Australian title, defeating Radek Stepanek 6-4, 6-3, 7-5 in the third round.

His victory came on the same day Lance Armstrong admitted during a television interview with Oprah Winfrey that he used banned drugs to win his seven Tour de France titles. Djokovic, a lifetime cycling fan, said at his post-match news conference that it was "a disgrace for the sport to have an athlete like this."

"He cheated the sport," Djokovic said. "He cheated many people around the world with his career, with his life story."

Djokovic did not have an easy time against the 31st-seeded Stepanek and was troubled at times by the Czech's serve-and-volley game. But Djokovic came out laughing, and he embraced his opponent over the net at the end. Stepanek even had chair umpire Carlos Bernardes grinning after producing an unexpected, over-the-shoulder winner to save one match point in the last game.

"Absolutely, it was great. Great match and great fun," Djokovic said. "It's always tricky to play Radek. He's a talented player. Skillful player."

Stepanek won 36 of the 67 points he played at the net, forcing Djokovic out of his comfort zone at the back of the court and making him work for every point.

"He's skillful on the net and he was not giving me a lot of rhythm ? he was changing up the pace on the ball," Djokovic said. "Nowadays everything is based on the baseline. It's nice to see somebody coming to the net."

Djokovic will play Sunday against No. 15 Stanislas Wawrinka, who knocked out the last American man in the draw with a 7-6 (6), 7-5, 6-4 win over No. 20 Sam Querrey. For the second straight year, there will be no American men in the fourth round at Melbourne Park.

In the last match of the day, fourth-seeded David Ferrer finished off a 6-4, 6-2, 6-3 win over 2006 Australian finalist Marcos Baghdatis with an ace, advancing to a fourth-round match against Japan's Kei Nishikori.

No. 5 Tomas Berdych beat Austria's Jurgen Melzer 6-3, 6-2, 6-2 and will next play South Africa's Kevin Anderson, who beat No. 22 Fernando Verdasco 4-6, 6-3, 4-6, 7-6 (4), 6-2. Djokovic's Serbian Davis Cup teammate Janko Tipsarevic advanced to a meeting with No. 10 Nicolas Almagro.

In an all-Serbian match of two former No. 1 women, 2008 French Open champion Ana Ivanovic beat Jelena Jankovic 7-5, 6-3. She moved into the fourth round against Poland's Angieszka Radwanska, who is seeded No. 4 and won her 12th straight match ? including titles at Auckland and Sydney ? with a 6-3, 6-1 defeat of Britain's Heather Watson.

No. 5 Angelique Kerber and No. 19 Ekaterina Makarova, two of the four women who beat Serena Williams in 2012, will meet in the fourth round. Kerber stopped 17-year-old American Madison Keys 6-2, 7-5 in the opening match at Rod Laver Arena, then blew out the candles on a cake to celebrate her 25th birthday. The crowd sang "Happy Birthday."

Makarova, who beat Williams in the fourth round in Australia last year, had a 6-7 (4), 6-3, 6-4 win over 2007 Wimbledon finalist Marion Bartoli.

No. 6 Li Na, the 2011 French Open winner, eliminated No. 27 Sorana Cirstea of Romania 6-4, 6-1 and will next play No. 18 Julia Goerges. Goerges prevented an all-China fourth-round encounter by beating Zheng Jie 6-3, 1-6, 7-5. Kirsten Flipkens of Belgium beat Valeria Savinykh 6-2, 4-6, 6-3 and is up against Sharapova next.

All along, Sharapova had been preparing for this third-round match. She withdrew from an exhibition tournament and the Brisbane International with a sore collarbone, but hasn't showed any signs of being troubled by it Melbourne.

"I think when we both looked at the draw, it was a matchup we were both looking forward to," Sharapova said. "I was just really determined out there because I knew the tennis that she's capable of producing and playing. She's a tremendous athlete and a great champion."

Sharapova's exuberant celebrations had little effect on Venus Williams. She barely acknowledged it as she made her way from the court.

"Definitely not my best today, but there's always other days to play better," she said. "I just had a lot of errors. ... That never helps."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-01-18-TEN-Australian-Open/id-f735f93b44924eb4bbe815b332a37c71

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Developing Minds Wants to Know: Q&A with Dana Morgan of The Melody Book

Dana Morgan is the CEO and Co-Founder of The Melody Book, a company that develops musical and educational applications, including A Jazzy Day and Jazzy ABC, for iOS. Their wonderful apps have been showcased in Apple?s ?New and Noteworthy? section, plus they have received a Children?s Technology Review award and a Parents Choice award.

In this interview, Dana discusses what it takes to create a successful application that is embraced by educators and parents, developers that inspire her, innovation, and the current technical restraints for developing iOS apps.


Key Company Facts

Name and Title: Dana Morgan, CEO and Co-Founder

Company: The Melody Book

Location: New York

Primary Apps/Platforms: A Jazzy Day, Jazzy ABC, Jazzy 123 (iPhone/iPad)


APPOLICIOUS: What inspired you to become an app creator?

Dana Morgan: My background is in software development and I've been programming web-based applications for the past 10 years. When iOS came out, I was excited to see all the possibilities that this platform presented. As the iTunes App Store continued to expand, I was drawn to the possibilities the app market had to offer.

APPO: How long have you been developing apps, and what is the most significant difference between now and when you began?

DM: I've been developing apps for three years now. Back then, there weren?t many apps on the iTunes App Store and today, there?s a remarkable difference in the quantity and quality of the apps. I believe that there still remains much ?potential to innovate and create great apps, even in a more crowded market.

Check out this video for A Jazzy Day:

APPO: What apps (outside of those that you develop) inspire you the most and why?

DM: There are so many apps that are inspiring. Aside from inventive apps, such as Dropbox, Waze and Pulse, I really appreciate the apps that have a great user experience such as Paper by FiftyThree, Flipboard, StumbleUpon!, Hootsuite and Camera+. This is something that I pay attention to, and I really believe that a great user experience makes a good app a best seller.

APPO: Where do you see the most innovation in the app sector?

DM: There is much innovation happening in education at the moment on the App Store. From educational apps that help special need students, to electronic books which have the potential to replace traditional school text books. Apple has really revolutionized the classroom by creating a new experience with the iPad. Now, it?s a proven and amazing educational tool for kids and is embraced by an increasing number of parents.

APPO: How do you harness that innovation in your own titles?

DM: We create music-related apps, and in the past year, we've been focusing on early childhood education. I can say that this field has really been booming and we've been seeing some innovative new apps. iPad and iPhones are amazing devices that keep kids engaged and force developers to focus on core functionality and keep things simple and concise. We are finally able to create products for kids that display hi-res animation, sound and interactivity that help their development from an early stage.

APPO: In such a crowded space, explain how you generate awareness and drive downloads to your applications.

DM: The App Store has indeed become more crowded and we are always looking for new ways to increase sales and brand recognition. Apple has featured our apps ?A Jazzy Day?, ?Jazzy ABC? and ?Jazzy 123? in ?New and Noteworthy? and on ?What?s Hot? and ?Recommended apps for Parents? lists, which was helpful in gaining awareness. We?ve also won a Children?s Technology Review award and a Parents? Choice award. I guess the best way to find out what works and what doesn't is to experiment with different marketing strategies and to keep refining your apps, based on consumer feedback.

APPO: What are the biggest technical constraints that exist today in the app sector?

DM: The biggest technical constraint would be the device constraint, such as memory allocation, Wi-Fi and 4G connection speed. In order to create more complex apps, we will need stronger and more capable devices that can perform multiple tasks seamlessly and keep up with the increasing demand for HD video and audio.

APPO: How do you (or will you) make money from your application?

DM: We sell most of our apps for a fixed price per download, and our next release will include in-app purchases.

APPO: What advice do you have to those working on their first applications?

DM: My advice would be to try and bring something fresh to App Store consumers. There are so many apps at this point that simply having a good app is not enough. Users have become very demanding and picky with purchases, so you should work on developing a good reputation for delivering great apps, which takes time and ingenuity.

APPO: Where do you see the app sector one year from now? Five years from now?

DM: Five years from now, technology advancements will bring a substantial increase in the complexity of apps. The majority of people will have smartphones. This means we?ll be seeing many more users, innovation and development. With this, we can expect a noticeable growth of competition on the market.

Download the Appolicious Android app

Source: http://www.appolicious.com/tech/articles/13145-developing-minds-wants-to-know-q-a-with-dana-morgan-of-the-melody-book

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Saturday, January 19, 2013

Cell: Protein folding via charge zippers

Cell: Protein folding via charge zippers [ Back to EurekAlert! ] Public release date: 18-Jan-2013
[ | E-mail | Share Share ]

Contact: Monika Landgraf
presse@kit.edu
49-721-608-47414
Helmholtz Association of German Research Centres

This press release is available in German.

Membrane proteins are the "molecular machines" in biological cell envelopes. They control diverse processes, such as the transport of molecules across the lipid membrane, signal transduction, and photosynthesis. Their shape, i.e. folding of the molecules, plays a decisive role in the formation of, e.g., pores in the cell membrane. In the Cell magazine, researchers of Karlsruhe Institute of Technology and the University of Cagliari are now reporting a novel charge zipper principle used by proteins to form functional units (DOI: 10.1016/j.cell.2012.12.017).

"It is fascinating to see the elegant basic principles that are used by nature to construct molecular assemblies," explains Anne Ulrich, Director of the KIT Institute for Biological Interfaces. "A charge zipper between the charged side chains is an entirely unexpected mechanism used by membrane proteins to neutralize their charges such that they can be immersed into hydrophobic cell membranes."

In the study published now, Ulrich and her team investigate the so-called Twin-arginine translocase (Tat) that is used in the cell membrane of bacteria as an export machinery for folded proteins. Several TatA subunits assemble as a pore that can adapt its diameter to the size of the cargo to be transported. "But how can such a pore be built up from TatA proteins? How can they reversibly form a huge hole in the membrane for a variety of molecules to pass through, but without causing leakage of the cell?", Ulrich formulates the questions studied.

To answer these questions, the researchers studied the molecular structure of TatA protein from the bacterium B. subtilis, which consists of a chain of 70 amino acids. The analysis showed that it folds into a rather rigid, rod-shaped helix that is followed by a flexible, extended stretch. Many amino acids in the helix and the adjacent stretch carry positive or negative charges. Surprisingly, the sequence of charges on the helix is complementary to those in the adjacent stretch of the protein. When the protein is folded up at the connection point like a pocket knife, positive and negative charges will always meet and attract each other. Hence, the protein links up both of its segments, similar to the interlocking teeth of a zipper.

"The clou is that this binding principle also works with the neighboring proteins," Ulrich says. Instead of folding up alone, every TatA protein also forms charge zippers with both of its neighbors. Computer simulations showed that this leads to stable and, at the same time, flexible connections between the adjacent molecules. In this way, any number of proteins can be linked together to form an uncharged ring, which thus lines the TatA pore in the hydrophobic membrane. This novel charge zipper principle does not only seem to play a role in protein transport, but also in the attack of certain antimicrobial peptides on bacteria, or in their formation of biofilms as a response to stress.

###

More information on the working group: http://www.ibg.kit.edu/nmr/.

Karlsruhe Institute of Technology (KIT) is a public corporation according to the legislation of the state of Baden-Wrttemberg. It fulfills the mission of a university and the mission of a national research center of the Helmholtz Association. KIT focuses on a knowledge triangle that links the tasks of research, teaching, and innovation.

This press release is available on the internet at www.kit.edu.

The photo of printing quality may be downloaded under www.kit.edu or requested by email or phone. The photo may be used in the context given above exclusively.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Cell: Protein folding via charge zippers [ Back to EurekAlert! ] Public release date: 18-Jan-2013
[ | E-mail | Share Share ]

Contact: Monika Landgraf
presse@kit.edu
49-721-608-47414
Helmholtz Association of German Research Centres

This press release is available in German.

Membrane proteins are the "molecular machines" in biological cell envelopes. They control diverse processes, such as the transport of molecules across the lipid membrane, signal transduction, and photosynthesis. Their shape, i.e. folding of the molecules, plays a decisive role in the formation of, e.g., pores in the cell membrane. In the Cell magazine, researchers of Karlsruhe Institute of Technology and the University of Cagliari are now reporting a novel charge zipper principle used by proteins to form functional units (DOI: 10.1016/j.cell.2012.12.017).

"It is fascinating to see the elegant basic principles that are used by nature to construct molecular assemblies," explains Anne Ulrich, Director of the KIT Institute for Biological Interfaces. "A charge zipper between the charged side chains is an entirely unexpected mechanism used by membrane proteins to neutralize their charges such that they can be immersed into hydrophobic cell membranes."

In the study published now, Ulrich and her team investigate the so-called Twin-arginine translocase (Tat) that is used in the cell membrane of bacteria as an export machinery for folded proteins. Several TatA subunits assemble as a pore that can adapt its diameter to the size of the cargo to be transported. "But how can such a pore be built up from TatA proteins? How can they reversibly form a huge hole in the membrane for a variety of molecules to pass through, but without causing leakage of the cell?", Ulrich formulates the questions studied.

To answer these questions, the researchers studied the molecular structure of TatA protein from the bacterium B. subtilis, which consists of a chain of 70 amino acids. The analysis showed that it folds into a rather rigid, rod-shaped helix that is followed by a flexible, extended stretch. Many amino acids in the helix and the adjacent stretch carry positive or negative charges. Surprisingly, the sequence of charges on the helix is complementary to those in the adjacent stretch of the protein. When the protein is folded up at the connection point like a pocket knife, positive and negative charges will always meet and attract each other. Hence, the protein links up both of its segments, similar to the interlocking teeth of a zipper.

"The clou is that this binding principle also works with the neighboring proteins," Ulrich says. Instead of folding up alone, every TatA protein also forms charge zippers with both of its neighbors. Computer simulations showed that this leads to stable and, at the same time, flexible connections between the adjacent molecules. In this way, any number of proteins can be linked together to form an uncharged ring, which thus lines the TatA pore in the hydrophobic membrane. This novel charge zipper principle does not only seem to play a role in protein transport, but also in the attack of certain antimicrobial peptides on bacteria, or in their formation of biofilms as a response to stress.

###

More information on the working group: http://www.ibg.kit.edu/nmr/.

Karlsruhe Institute of Technology (KIT) is a public corporation according to the legislation of the state of Baden-Wrttemberg. It fulfills the mission of a university and the mission of a national research center of the Helmholtz Association. KIT focuses on a knowledge triangle that links the tasks of research, teaching, and innovation.

This press release is available on the internet at www.kit.edu.

The photo of printing quality may be downloaded under www.kit.edu or requested by email or phone. The photo may be used in the context given above exclusively.


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Source: http://www.eurekalert.org/pub_releases/2013-01/haog-cpf011813.php

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Wednesday, January 16, 2013

Oil price flat

OilRig

http://www.sxc.hu/

Oil prices were nearly unchanged Tuesday after industrial production shrank in the 17 countries that use the euro, raising concerns of a prolonged recession in the region.

Benchmark crude for February delivery was up 3 cents to $94.17 per barrel at late aftenroon Bangkok time in electronic trading on the New York Mercantile Exchange. The contract rose 58 cents to finish at $94.15 per barrel in New York on Tuesday.

Industrial output across the eurozone fell in November for the third straight month, the European Union statistics office said Monday. The worse-than-expected 0.3 percent monthly decline was felt across the whole economy and sparked worries that it was a sign the current recession might linger.

?The weaker than expected European industrial production ... has seen Brent and US crude prices remain under pressure,? Michael Hewson, senior market analyst at CMC Markets, said in a market commentary.

Brent crude, used to price international varieties of oil, rose 27 cents to $111.22 per barrel on the ICE Futures exchange in London.

In other energy futures trading on the Nymex:

- Wholesale gasoline was up 0.1 cent at $2.773 a gallon.

- Natural gas fell 2.6 cents to $3.347 per 1,000 cubic feet.

- Heating oil rose 0.8 cent to $3.071. - Sapa-AP

Source: http://www.iol.co.za/oil-price-flat-1.1452251

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'50 die' in Syria university blasts

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Source: http://news.uk.msn.com/world/50-die-in-syria-university-blasts

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Monday, January 14, 2013

Israel Vows to Build in West Bank Site After Evicting Protesters (Voice Of America)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/276704009?client_source=feed&format=rss

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Schools duck 'moral duty' to dish up healthy meals ? Steve Beasant

Academies and free schools are failing in their ?moral duty? to ensure children are getting healthy school meals, local government leaders are warning.

The Local Government Association is concerned that more than one million children attending independently run free schools or academies could be eating poor quality meals that don?t meet legal food standards because of a worrying exemption in legislation.

Unlike council maintained schools, academies and free schools can opt out of the national food standards that stop canteens dishing up turkey twizzlers or installing vending machines full of crisps, chocolate and sugary drinks.

The LGA is now urging government to introduce one single food standard applicable to all schools to ensure every child has the best opportunity to receive a nutritious school lunch.

It comes as councils across the country are gearing up to take on a greater public health role from April, which will include responsibilities such as tackling childhood obesity and delivering the National Child Measurement Service.

This will give local authorities an even greater role in ensuring the health and fitness of our children. One of the key factors of this will be giving children a good and healthy school lunch while also teaching them about the importance of good food.

Councillor David Simmonds, Chairman of the LGA?s Children and Young People Board, said:

?With councils taking up the challenge of tackling obesity and poor diet as part of their new public health responsibilities, the last thing we need is to see junk food back on the menu in our local schools. This is of particular concern for children having free school meals where school lunch is often their main meal of the day.

?We know parents want school lunches that are healthy and nutritious, whatever type of school their child attends. School autonomy is supposed to drive up standards but in the case of school meals we now have a two-tier system where one type of school can effectively exempt pupils from healthy choices and instead sell fatty and sugary foods. This threatens to seriously impact on the health and educational attainment of our children.

?As champions for parents and children, councils with new public health responsibilities will want to hold all schools to account if they are ducking their moral duty to give students the best chance of living a happy and healthy life.

?History shows us that voluntary guidelines alone do not work to drive up standards. We now need government to do its part by introducing an acceptable food standard that will allow councils to hold all schools to account for the nutritional quality of food they serve their pupils.?

According to research by the Children?s Food Trust, nine in ten academies are selling children junk food such as crisps, chocolate and cereal bars that are banned in maintained schools to protect pupil?s health.

One in six schools reported selling confectionery, one in four sold crisps and savoury snacks, more than half sold cereal bars ? often as high in sugar as confectionery ? and more than three-quarters sold soft drinks.

The same study showed that academies can make between ?3,000 and ?15,000 a year from selling junk food to their pupils.

Currently more than 50 per cent of secondary schools in England are either academies or in the process of becoming academies and there is a growing number of primary schools also converting. In addition, a further 102 new free schools have been approved to open in 2013 and beyond.

More than 1,250,000 pupils now attend academies, which means around one in seven pupils in state schools now attends an academy school. This increases to one in three pupils in state secondaries.

The law on nutritional standards was tightened in England for local authority primary schools in 2008 and secondaries in 2009.

Source: http://stevebeasant.mycouncillor.org.uk/2013/01/13/schools-duck-moral-duty-to-dish-up-healthy-meals/

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Saturday, January 12, 2013

Oil Spill Cleanup Could Kill Coral

By Breanna Draxler | January 11, 2013 11:02 am

Mustard hill coral (Porites asteroides)

When the Deepwater Horizon oil rig blew in 2010, it spewed some 200 million gallons of oil into the Gulf of Mexico. In order to break up the slick, another 1.84 million gallons of dispersant was added to the mix. This one-two punch of toxic chemicals devastated coastal ecosystems [pdf], but how would such a chemical bombardment affect underwater ecosystems like coral reefs? According to a new study, the picture is no prettier.

Researchers at the?Mote Marine Laboratory in Florida tested the effects of Deepwater Horizon-type oil and the dispersant used to clean it up, Corexit? 9500int, on coral larvae in the lab to replicate what may have happened following the spill. Larvae colonize reefs by sampling a surface, sticking to it and then changing into a polyp to get growing. They do this based on chemical cues in the water. Adding oil and dispersant, it turns out, severely hinders this sensitive settlement process.

Researchers tested two kinds of coral larvae from the Florida Keys?mustard hill coral (Porites astreoides) and mountainous star coral (Montastraea faveolata). Although these species were not directly affected by the spill, their behaviors are indicative of coral larvae in general. Researchers recorded the larvae?s behavior, settlement and survival rates when exposed to different combinations and concentrations of the chemicals. In the presence of oil alone, coral larvae were less likely to settle and their chances of survival were slim. When exposed to both dispersant and oil, chances of survival dropped to almost none.

Reefs are already endangered, so damage that inhibits growth is especially worrisome. Lab studies like this done in advance of our next oil spill, however, may ensure that cleanup does less harm in the future.

?Image courtesy of nashworld / Flickr

Source: http://feedproxy.google.com/~r/80beats/~3/s-w7jnJV19Y/

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Mexico City spay/neuter campaign aims to reduce stray population [Photos]

Photo: Alfredo Estrella/AFP/Getty Images

A young, responsible pet owner

Jesus Garcia, 10, holds his dog 'Luna', after the pup underwent a sterilization surgery on Jan. 10 at free pet clinic event in the Las Golondrinas neighborhood in Mexico City, Mexico.

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In response to the swelling stray animal population in Mexico City, the local government kicked off a sterilization campaign to raise awareness and reduce the number of cats and dogs on the streets.

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Photo: Alfredo Estrella/AFP/Getty Images

Under the knife

A dog lies unconscious on a stretcher as veterinarians perform a sterilization surgery on Jan. 10 inside a mobile surgery module at a pet clinic event in the Las Golondrinas neighborhood of Mexico City, Mexico.

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In the U.S., approximately 4 million cats and dogs are euthanized at shelters every year because there is simply not enough homes for all of them. The most effective way to reduce overpopulation is to spay or neuter pets within a few months after their birth.

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Photo: Alfredo Estrella/AFP/Getty Images

Breaking the cycle

A cat waits for its turn to be sterilized inside a mobile surgery module on Jan. 10 during a pet clinic event in the Las Golondrinas neighborhood of Mexico City, Mexico.

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In addition to preventing reproduction, getting your pet sterilized is generally better for their health overall. Cats are 92 percent less likely to develop breast cancer if they are spayed before six months of age.

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Related content on MNN:

Source: http://www.mnn.com/earth-matters/animals/stories/mexico-city-spayneuter-campaign-aims-to-reduce-stray-population-photos

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Sensory Acumen?s Game Skunk Is Part Video Game Enhancer, Part Therapy Tool

sensoryacumen_logo1Eureka Park played home to a whole host of interesting companies and projects (some of which were arguably more interesting than the stuff you'd find on the actual CES show floor) and our first stop was clearly a winner. Meet California-based Sensory Acumen, the creators of curious a scent-generating device called the GameSkunk.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/jH-EanK8P-w/

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Thursday, January 10, 2013

ESPN NFL ? Divisional Playoffs Weekend

Post image for ESPN NFL ? Divisional Playoffs Weekend

ESPN?s NFL Divisional Playoffs Weekend will include Chris Berman, Cris Carter, Mike Ditka, Tom Jackson, Keyshawn Johnson, Suzy Kolber, Merril Hoge and Ron Jaworski hosting two editions of Sunday NFL Countdown ? a two-hour special Saturday, Jan. 12, at 10 a.m. ET, and the regular three-hour edition Sunday, Jan 6, at 10 a.m.? NFL Insider Adam Schefter and senior analyst Chris Mortensen will report the day?s news.

Sal Paolantonio will host NFL Matchup with analysts Merril Hoge and Ron Jaworski Saturday and Sunday at 3 a.m. each day (reairs on ESPN2 Saturday at 6 a.m.; and on ESPN Sunday at 6:30 a.m.).? NFL PrimeTime with host Trey Wingo will air on Saturday at midnight (9 p.m. PT) and Sunday at 9 p.m.

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ESPN?s NFL studio programming on Divisional Playoffs weekend:

Date Time (ET) Show
Fri, Jan 11 4 p.m. NFL Live presented by Radio Shack
Trey Wingo, Tedy Bruschi and Herm Edwards
5 p.m. NFL32
Suzy Kolber, Chris Mortensen, Bruschi and Mark Schlereth
7 p.m. NFL Kickoff
Wingo, Schlereth and Darren Woodson
Sat, Jan 12 3 a.m. NFL Matchup
Sal Paolantonio, Merril Hoge and Ron Jaworski
10 a.m. Sunday NFL Countdown presented by IBM (2 hours)
Chris Berman, Cris Carter, Mike Ditka, Tom Jackson and Keyshawn Johnson
11 p.m. SportsCenter
Trent Dilfer and Hoge
12 a.m. NFL PrimeTime
Wingo, Dilfer and Hoge
Sun, Jan 13 3 a.m. NFL Matchup
Paolantonio, Hoge and Jaworski
10 a.m. Sunday NFL Countdown presented by IBM (3 hours)
Berman, Carter, Ditka, Jackson, Johnson, Kolber, Hoge and Jaworski
9 p.m. NFL PrimeTime
Wingo, Dilfer
10 p.m. SportsCenter Special
Eric Mangini and Antonio Pierce
11 p.m. SportsCenter Special
Eric Allen, Dilfer and Pierce

Coverage will include pre- and post-game reports from all four stadiums. Saturday: Sal Paolantonio (Baltimore at Denver) and Colleen Dominguez (Green Bay at San Francisco). Sunday: Josina Anderson (Seattle) and Ed Werder (Atlanta) will split coverage of the teams playing at Georgia Dome, and Rachel Nichols (Houston at New England).On-site reporters at the four NFL Divisional Playoff Weekend games:

Sunday NFL Countdown (Saturday):

  • ?Soundtracks? on Ray Lewis? Wild Card Game ?Countdown relives Ray Lewis? last home game as the Baltimore Ravens? inspirational leader from introductory dance through the end-of-game celebration during the Wild Card game.
  • John Harbaugh with Berman ? Ravens John Harbaugh will coach his team in a Divisional Playoff game for the fifth straight season. Countdown?s Chris Berman travelled to Baltimore this week for an interview with Harbaugh who talks about Ray Lewis announcing his retirement, quarterback Joe Flacco?s up and down season and the success of his brother/coach Jim Harbaugh is having with the San Francisco 49ers.
  • Elway with Tommy ? Former teammates ? Denver Broncos executive vice president John Elway and Countdown?s Tom Jackson ? reunite to discuss the team?s turnaround ? winning 11 straight games ? and how he convinced quarterback Peyton Manning to sign with the Broncos.
  • Kaepernick?s Dream ? While in fourth grade, 49ers quarterback Colin Kaepernick wrote a letter expressing his desire to one day play for the team or his hometown team, the Green Bay Packers.? Reporter Colleen Dominguez traces Kaepernick?s story ? raised by adopted parents and how he persevered to make his dream come true.

Sunday NFL Countdown (Sunday):

  • Tom Brady with Berman ? Before beginning another playoff campaign, quarterback Tom Brady sat down with Berman for a interview where he discusses his team?s two Super Bowl losses in the last five years, recaps the season, fatherhood and his future in the game.
  • Matt Ryan?s Quest ? After three straight losses in the playoffs, many are beginning to question whether quarterback Matt Ryan will win his first playoff game. ESPN.com?s Greg Garber explores Ryan?s quest to get over the proverbial hump and includes interviews with notable former quarterbacks, Elway and Randall Cunningham who experienced failure in the playoffs early in their careers
  • The D Block! ? The Falcons ?D Block? is arguably the most entertaining show in football. Each week, the Atlanta Falcons? linebackers host a show in the locker room that includes special guests and their unique brand of comedy, music and witty interviews.
  • J.J. Watt Biggest Impact ? The Houston Texans defensive end J.J. Watt is making a major impact on and off the field.? Watt befriended two brothers in Houston paralyzed in a car crash that killed their parents. ESPN.com columnist and Countdown essayist Rick Reilly reports how Watt has impacted the lives of this family.
  • Richard Sherman ?Soundtracks? ? In-game audio and highlights from the ebullient Seattle cornerback Richard Sherman in their Wild Card game last Sunday at Washington.

NFL Matchup (Saturday):

  • Jaworski shows how the 49ers use an unconventional formation to dictate a favorable matchup that repeatedly leads to wide receiver Michael Crabtree vs. a linebacker
  • Hoge describes a blitz scheme using second- and third-level defenders that the Broncos used to pressure Ravens quarterback Joe Flacco in their week 15 game.
  • Jaworski uses the telestrator to show how Broncos quarterback Peyton Manning takes advantage of man coverage with his big wide receivers running unique double-move routes.
  • In week 15, the Ravens? run game was most successful in single-back, Jaworski explains why and how.
  • Disregard the 49ers at Packers week one game, contends Hoge, explaining how Packers quarterback Aaron Rodgers has become more successful late in the season by using his legs to avoid pressure.
  • Though the 49ers appear to be a pass-heavy team since the change to quarterback Colin Kaepernick, they are still a run-first offense. Hoge uses the ?Coaches Clicker? to show why.
  • Jaworski shows how the 49ers disguised blitzes in week one to produce three sacks of quarterback Aaron Rodgers.

NFL Matchup (Sunday):

  • Quarterback Russell Wilson has impressed critics with his ability to make plays with his legs. Jaworski shows a 49 yard-completion that exemplifies the Seattle Seahawks signal-caller?s ability to make throws on the run.
  • Arguing that the Seahawks? and Carolina Panthers? offenses are similar, Hoge analyzes key plays in the Panthers offense that led to 394 rushing yards in their two meetings with the Falcons this season.
  • Jaworski, using the telestrator, shows how the New England Patriots run-action to draw the safeties down opened up lanes for an easy touchdown throw to wide receiver Brandon Lloyd in their last meeting vs. the Texans
  • Jaworski explains how the Falcons? motion and unconventional alignments can mollify the Seahawks? potent press coverage.
  • Falcons? tight end Tony Gonzalez has the most third-down catches this year and Hoge shows how he wins against man or zone coverage.
  • JJ Watt and the Texans defense must get pressure on Tom Brady to contain the Patriots pass attack, and Hoge pulls out the ?Coaches Clicker? to explain a successful zone-blitz the Texans used in their last meeting.
  • The Patriots defense held running back Arian Foster to 46 yards in Week 14 playing in multiple defensive fronts. Hoge shows how the Patriots? key is sustained penetration.
  • Jaworski analyzes Matt Schaub?s interception in the Texans first meeting with the Patriots, showing how the quarterback needs to manipulate the safety before making deep throws downfield.
  • Jaworski shows Vince Wilfork?s dominance against the run in the Texans at Patriots week 14 game.

NFL Divisional Playoff Coverage on ESPN.com and ESPN Radio

ESPN Radio and ESPN.com will cover the NFL Divisional Playoffs leading up to and following the four weekend games. Highlights:

ESPN Radio?s Countdown to Kickoff (Saturday 1-4 p.m., Sunday 10 a.m.-1 p.m.) with host Freddie Coleman will preview each day?s action. Guests include analysts Tom Jackson, Ron Jaworkski and Merril Hoge, insiders Chris Mortensen and John Clayton, and on-site game reporters as well as newsmakers from around the league. Weekend programming will also feature extensive post-game coverage of each game.

ESPN.com writers and bloggers will cover all four Divisional Playoff games. Anticipated staff assignments:

On Sunday, ESPN.com will post a NFC Championship Q&A written by Clayton and an AFC Championship Q&A by senior writer Jeffri Chadiha.

SportsCenter Special with Bill Parcells to Preview Conference Championships

Two-time Super Bowl-winning head coach Bill Parcells will preview the NFL Conference Championship games in a 30-minute SportsCenter Special on Wednesday, Jan. 16, at 7 p.m. on ESPN. Parcells will be joined by host Trey Wingo and analyst Keyshawn Johnson as he discusses the NFC and AFC Championship games and his experience coaching in these games during his 19 seasons as a head coach.

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Related posts:

Source: http://www.tmrzoo.com/2013/41889/espn-nfl-divisional-playoffs-weekend

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Exclusive: Shawty Lo Says He's 'Providing' For All His Babies' Mamas

'I'm taking care of my kids,' rapper tells MTV News in an exclusive interview about his 11 children and 10 baby mothers.
By Rob Markman, with reporting by FLX


Shawty Lo
Photo: MTV News

Source: http://www.mtv.com/news/articles/1699857/shawty-lo-family-kids-exclusive.jhtml

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